Celiachia e difetti dello smalto in età evolutiva: correlazione tra periodo di esposizione al glutine, forme cliniche di celiachia e aplotipo HLA
Flocchini, Pierangela (2011) Celiachia
e difetti dello smalto in età evolutiva: correlazione tra periodo di
esposizione al glutine, forme cliniche di celiachia e aplotipo HLA
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Abstract
The
association between celiac disease (CD) and dental enamel defects (DED)
is well known. AIM: This study was designed to investigate the
prevalence of DED in CD children and to specifically find a possible
correlation between DED and gluten exposure period, CD clinical forms,
HLA class II haplotype.
MATERIALS AND METHODS: This study was designed as a matched case-control
study: 374 children were enrolled (187 celiac and 187 non celiac). Data
about age at CD diagnosis, CD clinical form and HLA haplotype were
recorded.
RESULTS: DED were detected in 87 celiac subject while no dental lesions
were found in the remaining 100 patients; in 187 healthy controls enamel
lesion were significantly less frequent (5.3 % versus 46.5% ;
p<0.005).We found a correlation between DED and gluten exposure
period, since among CD patients the mean age at CD diagnosis was
significantly (p= 0.0004) higher in the group with DED (3.41± 1.27) than
without DED (1.26± 0.7). DED resulted more frequent in atypical and
silent forms than in the typical one. The presence of HLA DR 52-53 and
DQ7 antigens significantly increased the risk of DED (p=0.0017).
CONCLUSIONS: Our results confirmed a possible correlation between CD
clinical form, age at CD diagnosis, HLA antigens and DED. The origin of
DED in CD children is due to multifactorial events and further studies
are needed to investigate other determinants.
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Autore: | Flocchini, Pierangela |
| Relatore: | Majorana, Alessandra |
| Dottorato di ricerca: | Scienze mediche generali e scienze dei servizi: progetto n. 2 "Odontoiatria per disabili" |
| Scuola di dottorato: | Scienze Mediche e Chirurgiche |
| Settori disciplinari: | Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche |
| Parole chiave: | celiachia HLA bambini ipoplasia dello smalto |
| URN:NBN: | urn:nbn:it:unibo-2851 |
| Data di discussione: | 2011 |
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